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Hyperforin

 

Product name : Hyperforin


IUPAC Name : (1R,5R,7S,8R)-4-hydroxy-8-methyl-3,5,7-tris(3-methylbut-2-enyl)-8-(4-methylpent-3-enyl)-1-(2-methylpropanoyl)bicyclo[3.3.1]non-3-ene-2,9-dione Mol. Mol.

Formula :
  C35H52O4


Mol. Weight :
  536.78498 


CAS No. :
11079-53-1

Botanical Source :
 Hypericum perforatum, St. Johns Wort


Catalogue No. :
H08001

Purity :
> 98%,99% by HPLC


Package :
20mg, 50mg,100mg, 1000mg,10g,100g...


Remark :
In stock, customized for large scale.

Introduction :
Hyperforin is one of the key phytochemical actives found in St. John's Wort(Hypericum perforatum). Generally, it designated in percentile, meaning that if a 100 mg dose of St. John's Wort is extracted at a standardized 5%, you will get about 5 milligrams of hyperforin from that dose.
Hyperforin is a prenylated phloroglucinol believed to be the main active constituent responsible for its antidepressant effects. (Barnes et al., 2002) Hyperforin has been shown to inhibit the uptake of 5-HT(serotonin), dopamine, noradrenaline, GABA and glutamate. (Chatterjee et al., 1998) Hyperforin is also thought to be responsible for the induction of the cytochrome P450 enzymes CYP3A4 and CYP2C9 by binding to the Pregnane X Receptor (PXR).
Biochemical research demonstrates that hyperforin - like many prescription antidepressants - inhibits the reuptake of the neurotransmitters norepinephrine, serotonin, and dopamine. These are the chemicals that help to send the message to and from the brain. If wrong Neurotransmitters are produced the body works inefficiently in some way and illness results. Many of the anti-depressants that are used are made up of a substances designed to correct these imbalances that exits.     Hyperforin acts as a "reuptake inhibitor" and increases the levels of these neurotransmitters in the brain, which further improves mood and restore emotional balance. Hyperforin also inhibits the reuptake of GABA which is a neurotransmitter associated with increasing relaxation and reducing anxiety.
Furthermore, potencies of two different hypericum extracts useful for the detection of antidepressants (behavioral despair, learned helplessness), closely correlate with their hyperforin contents. In addition to this, most of the neuropharmacological properties of the clinically used hypericum extracts can also be demonstrated with pure hyperforin. It appears, therefore, that this non-nitrogenous constituent is a possible major active principle responsible for the observed clinical desired effects of the extract as an antidepressant and that it could also be a starting point for drug discovery projects.

References :
1,Barnes J, Anderson LA, Phillipson JD (2002). Herbal Medicines: A guide for healthcare professionals (2 ed.) London: Pharmaceutical Press. ISBN 0-85369-474-5
2,Chatterjee SS, Bhattacharya SK, Wonnemann M, Singer A, Muller WE (1998a). Hyperforin as a possible antidepressant component of hypericum extracts. Life Sci 63 (6), 499-510.

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