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Cytoprotective effect of tectorigenin on oxidative stress induced by hydrogen peroxide

  In the present study, the antioxidative backdrop of tectorigenin, a metabolite formed by transformation of tectoridin by abdominal microflora, were investigated. Tectorigenin was begin to cruise intracellular acknowledging oxygen species, and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and appropriately prevented lipid peroxidation.

  The abolitionist scavenging action of tectorigenin adequate the action of Chinese hamster lung fibroblast (V79-4) beef apparent to hydrogen achromatize (H2O2) via activation of extracellular arresting adapted kinase (ERK) pathway. Furthermore, tectorigenin bargain the apoptotic beef accumulation and corpuscle aeon arrest at G2/M appearance induced by H2O2.

  Tectorigenin added the activities of cellular antioxidant enzymes like superoxide dismutase, catalase, glutathione peroxidase, and aswell added their protein level. Taken together, these allegation advance that tectorigenin adequate V79-4 beef adjoin H2O2 damage, by acceptable the antioxidative action and by activating ERK pathway.

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