Design and amalgam of isosteviol triazole conjugates for blight therapy

  One of the keys for auspiciously developing drugs adjoin the ample spectrum of blight corpuscle types is structural diversity. In the accepted study, we focused on a ancestors of isosteviol derivatives as abeyant atypical antitumor agents.
  Isosteviol is a tetracyclic diterpenoid acquired by acerbic hydrolysis of steviol glycoside extracts abandoned from abounding Stevia rebaudiana plants. In this work, we accept advised and actinic a console of isosteviol triazole conjugates application 'click' allure methodology. Evaluation of these compounds adjoin a alternation of blight corpuscle curve acquired from primary and metastatic tumors approved that these conjugates display cytotoxic activities with IC50 in the low μM range.
  In addition, their anti-proliferative activities are blight corpuscle blazon specific. Taken together, our studies accentuate the accent of structural assortment in accomplishing blight corpuscle blazon specific biologic development.