Cytotoxic furnishings of six isoflavonoids, tectorigenin, glycitein, tectoridin, glycitin, 6''-O-xylosyltectoridin, and 6''-O-xylosylglycitin abandoned from the annual of Pueraria thunbergiana Benth. calm with genistein, a accepted adverse and apoptosis inducer, were examined. Among these isoflavonoids, tectorigenin and genistein apparent cytotoxicity adjoin assorted animal blight cells; glycitein showed alone balmy cytotoxicity.
These after-effects advance that the isoflavone anatomy and 5-hydroxyl accumulation are acute for the cytotoxic backdrop and that glycosides are inactive. Moreover, tectorigenin induced adverse of animal promyelocytic leukemia HL-60 beef to granulocytes and monocytes/macrophages, and acquired apoptotic changes of DNA in the cells, as did genistein.
Tectorigenin aswell inhibited autophosphorylation of epidermal advance agency (EGF) receptor by EGF and decreased the announcement of Bcl-2 protein, with beneath action than genistein. From these results, tectorigenin may be a accessible ameliorative abettor for leukemia.
