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Inhibitory aftereffect of clay bean abstract and its accommodation vitexin and isovitexin on the accumulation of avant-garde glycation endproducts

  The anti-glycation action of four kinds of beans including clay bean, atramentous bean, soybean and cowpea were evaluated. Aqueous booze abstract of clay bean apparent the arch inhibitory action adjoin the accumulation of beaming avant-garde glycation endproducts (AGEs) in a bovine serum albumin (BSA)-glucose model, and the inhibitory activities of extracts of the four beans were begin to be awful activated with their absolute phenolic accommodation (R2 = 0.95).

  Subsequent HPLC appraisal of clay bean abstract appear two above phenolics which were antiseptic and articular as vitexin and isovitexin by ashen methods.

  In the anti-glycation assays, both vitexin and isovitexin showed cogent inhibitory activities adjoin the accumulation of AGEs induced by glucose or methylglyoxal with efficacies of over 85% at 100 μM. In addition assay, vitexin and isovitexin bootless to anon allurement acknowledging carbonyl species, such as methylglyoxal, suggesting that their anti-glycation activities may mainly be due to their chargeless abolitionist scavenging capacity.


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