As allotment of advancing appraisal on blight chemopreventive agents from botanical comestible supplements, Garcinia mangostana L. (commonly accepted as mangosteen) was called for abundant study. Repeated chromatography of a CH2Cl2-soluble abstract of the carapace led to the abreast of two new awful oxygenated prenylated xanthones, 8-hydroxycudraxanthone G (1) and mangostingone [7-methoxy-2-(3-methyl-2-butenyl)-8-(3-methyl-2-oxo-3-butenyl)-1,3,6-trihydroxyxanthone, 2], calm with 12 accepted xanthones, cudraxanthone G (3), 8-deoxygartanin (4), garcimangosone B (5), garcinone D (6), garcinone E (7), gartanin (8), 1-isomangostin (9), alpha-mangostin (10), gamma-mangostin (11), mangostinone (12), smeathxanthone A (13), and tovophyllin A (14). The structures of compounds 1 and 2 were elucidated by spectroscopic abstracts analysis. Except for admixture 2, which was abandoned as a accessory component, the antioxidant activities of all isolates were bent application accurate and morpholinosydnonimine-derived peroxynitrite methods, and compounds 1, 8, 10, 11, and 13 were the a lot of active. Alpha-mangostin (10) inhibited 7,12-dimethylbenz[alpha]anthracene-induced preneoplastic lesions in a abrasion mammary agency ability appraisal with an IC50 of 1.0 microg/mL (2.44 microM).
